Diacetyl - A Critical Safety Review of the Science Defining the Environmental Inhalation Hazards Association with Chronic Lung Disease

In the last two decades scrutiny of several retrospective occupational studies on performed by NIOSH in early 2000’s ambient indoor air exposures to flavoring chemical diacetyl and more complex butter formulations has led a reported association between severe irreversible lung disease, primarily bronchiolitis obliterans. A group laboratory rodent studies, associated researchers, followed next with intent determine plausible physiological mechanism for bronchiole scarring applicable human respiratory tract. Recently, renewed interest as constituent vaping liquids marijuana inhalation emerged. This paper reviews universe published literature date relation whether or flavors containing causes environmental specifically BO (i.e., general causation) specific levels inhaled are chronic disease.
 The review included numerous journal articles, government reports, etc. Based upon evidence, while reflects statistical both mixtures there is sufficient evidence conclude that causation exposure concentrations measured environments studied disease does not exist.